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Vascular normalization seeks to transiently improve vessel structure and function, including pericyte coverage, perfusion, oxygenation and drug distribution [11, 12, 68]

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Pharmaceutical development of Nrf2 modulators The identification of Nrf2 as a master regulator of cellular antioxidant defenses has revolutionized our understanding of its pivotal role as a therapeutic target in the pathogenesis of inflammatory diseases

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Detox Strategies To support detoxification pathways in the presence of MTHFR mutations, consider the following strategies: Optimize nutrition: Focus on a nutrient-dense diet rich in antioxidants and vitamins that support methylation, such as B vitamins (B6, B12), folate (preferably in its active form, methylfolate), and glutathione-rich foods (e.g., cruciferous vegetables)