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Given the multifactorial nature of glaucoma-associated ocular surface disease (G-OSD)which involves chronic inflammation, oxidative stress, and tear film instabilitydeveloping novel therapies that target these intersecting pathways is of considerable clinical relevance

Curr Opin Toxicol

Although homocysteine thiolactone has not been unequivocally identified in vivo , it might be a major by-product of deregulated homocysteine metabolism

The presence of astrocytes in cultures was assessed through quantification of the expression of Glial Fibrillary Acidic Protein (GFAP) [1,250, G3893]

Over the past decade, however, researchers are discovering that environmental factors like radiation, pollution, heavy metals and chemicals in the soil and water may be even more responsible for the increase in oxidative stress and chronic diseases