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Exercise is an important part of whole person care with multiple other benefits, and exercise should be prescribed along with the much-needed pharmaceuticals, such as GLP1a's or metformin, for multiple reasons such as reducing side effects such as sarcopaenia

The pathway is itself sensitive to other nutritional cofactors, including B-vitamin status and the broader sulphur amino acid pool

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On days 13, plasma dUrd levels were significantly higher than baseline, and this may suggest rapid TS inhibition after dosing