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Ramachandram DS, Damodaran T, Zainal H, Murugaiyah V, Ramanathan S Pharmacokinetics and pharmacodynamics of mitragynine, the principle alkaloid of Mitragyna speciosa: present knowledge and future directions in perspective of pain

For example, polylactic acid-glycolic acid copolymer (PLGA) nanoparticles can extend the drug release cycle to 72 hours

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Phytoestrogens and their effects