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Existing clinical studies often suffer from single-center experiments, small sample sizes, short follow-up durations, and the absence of standardized endpoint measures, which challenge comparative analyses across studies and the establishment of conclusive evidence

The mechanism may be related to metformin regulating glycolysis-related mediators to improve ovarian energy metabolism (Zhang et al., 2020)

In addition, the results of a multicenter, double-blind, randomized controlled trial showed that for COPD patients with vitamin D deficiency, vitamin D supplements did not reduce the exacerbation rate of their condition (166), and the supplement did not improve lung function in all individuals, but it was beneficial for regular smokers (167, 168)

In Medical Image Computing and Computer Assisted Intervention MICCAI 2018 (eds Frangi, A