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doi: 10.3389/fimmu.2022.1039241 107 ZhongY.LiangB.ZhangX.LiJ.ZengD.HuangT.et al

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in heat stress-induced ALI, heat stimulation can significantly increase EVs released by hepatocytes, thereby promoting liver injury, while the EVs synthesis inhibitor GW4968 can alleviate heat stress-induced liver injury [56]

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Initially, upon cell stimulation by signals, the UNC-51-like kinase 1 (ULK1) complex is detached from and activated by the mammalian target of rapamycin complex 1 (mTORC1) through a cascade reaction, thereby initiating autophagy (98)