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Two further classes of enzymes which contribute to superoxide production are NADPH oxidases of which several isoforms are present in RBC (George et al., 2013) and endothelial NO synthase which is present in human and mouse RBC (Kleinbongard et al., 2006) and produces O 2 when L-arginine levels are low (Mihov et al., 2009)

The infusion runs for 30 to 60 minutes depending on the formula

In addition, HTY exhibits iron and copper chelation properties, thereby limiting metal-catalyzed Fenton reactions and subsequent hydroxyl radical generation [5]