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The accumulation of ROS has been demonstrated to trigger the phosphorylation and activation of the key kinase p38 MAPK, suggesting that ROS is a potential activator of the MAPK signaling pathway [75]

Neuropharmacology 131 , 364376 (2018)

The cells were homogenized and the plates incubated for 30 min at 4 C

doi: 10.1080/00071660903401540

Hinokitiol is capable to alleviate excessive glutamate to induce ROS, lipid peroxidation, and Fe 2+ accumulation in neuronal cells and relieve brain tissue damage (Tang et al., 2023)