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Gene sequencing is useful and accurate, but it is relatively expensive and time consuming and not appropriate for routine detection

TNF is a trimeric ligand, while Fc-fusion biologicals (peptibodies) are dimeric, leading to potential complex binding modes, as shown in Figure 4, where the etanercept binds one TNF molecule with avidity, only one TNF or two TNF molecules, although it is not clear which binding model is more likely for Fc-receptor fusion binding to the trimeric TNF

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Epigenetic changes may also underlie epithelial barrier leakage

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