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Elevated oxidative stress has been strongly linked with aging and aging-related illnesses

Miller et al., 1993

These results supported the idea that trigger pairing specifies a trajectory of the 5 flank of the trigger RNA, which favours interaction with the ZSWIM8 NPAZ RBEs

blunt, 3-overhangs, frayed, panhandles, triphosphates, virus-derived peptides, 3D folds) could affect the route of uptake of dsRNAs and the activation of the dicing function of Dcr-2 as opposed to the non-specific induction of immunity