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and areas of fibrosis (FIB), shown in blue by Massons trichrome stain (Fig

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HAP, through its positively charged calcium units establishes chemical links with skin unsaturated fatty acids carboxylic groups, leading to their subtraction from skin surface (-43%), hence avoiding their exposure as substrates for the formation of ROS resulting from skin lipid peroxidation Despite its activity on skin unsaturated fats adsorption, hydroxyapatite does not affect skin sebometry, keeping a balanced equilibrium of the skin hydrolipidic film (analysis carried out through sebumeter SM 815, results are summarized in figure 3) with a consequent lack of comedogenic and pores clogging potential

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These results underscore the critical role of adipose NAD + in modulating adaptive thermogenesis, lipolysis, and overall energy metabolism