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Phenotypic examination indicated that treatment with PJ34 attenuated APAP-induced liver injury, as evidenced by decreased liver necrosis (Figure S5A, F), serum levels of ALT and AST (Figure S5E), apoptosis (Figure S5B, G), and oxidative damage in Sry -TG mice (Figure S5C, D, H, I)

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17 However, Park et al demonstrated that although no glutathione could be measured in the whole plasma compartment, GSH could be detected in the protein-bound fraction of the human blood between 60 and 120 minutes after oral intake