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The naturally occurring peptide GHK reverses age-related fibrosis by modulating myofibroblast function

The majority of circulating ghrelin exists as the des-octanoylated (des-acyl) form: octanoylated ghrelin constitutes approximately 1.8% of the total amount of circulating ghrelin (333)

doi: 10.1016/j.lindif.2015.01.004 52 Merwid-LadA.PassonM.DrymluchP.GuszyskiM.SzelgA.MatuszewskaA

This is consistent with the theory of local area network inhibition, which posits that excessive or unstable excitatory activity can induce homeostatic over-inhibition, thereby contributing to clinical symptomswhose precise manifestations depend on the neural networks involved

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