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Objective measurements More quantitative approaches include: Bloodwork: Tracking relevant biomarkers before, during, and after protocols

80,81 The overall prevalence of SFN in diabetes patients ranges from 20 to 30%, depending on the diagnostic criteria and population studied

Macro-B12 should be suspected when a markedly high value persists with no B12 exposure, sits with an unrevealing workup, and disagrees with functional markers