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In addition to these epidemiological and clinical observations, experimental confirmation in preclinical PD models, demonstrated that renal dysfunction directly promotes neurodegeneration by impairing the clearance of circulating syn, thereby validating the kidneybrain axis hypothesis [149]

Probiotics Probiotics are live microorganisms that confer health benefits when consumed in adequate amounts

Alveolar macrophages, mobile phagocytic cells residing in the lungs, play a dual role in both inflammation and tissue repair

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Although these inconcistencies are present, they do not hinder the validity of the AOP in its biological plausibility or empirical analsysis