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Misoprostol causes diarrhea and other gastrointestinal side effects relatively frequently, and is contraindicated in pregnant women because it can cause miscarriages and birth defects (Lee 2013

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The probability of developing advanced hepatic fibrosis is significantly greater in individuals with steatohepatitis than in those with simple steatosis.7,8 In most cases, fatty liver does not progress to end-stage liver disease, but approximately 20% to 30% of cases with NAFLD have histological signs of fibrosis, inflammation and necrosis, indicating the presence of NASH

Khoo NKH, Lim JME, Gill US, de Alwis R, Tan N, Toh JZN, et al