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Excessive ROS serve not only as a direct agent causing damage to biological macromolecules but also as a potent second messenger that activates key pro-inflammatory signaling pathways, such as NF-B and MAPK, through the oxidative modification of essential signaling proteins (62)

Extended use for ongoing cognitive support appears reasonable

10.1093/humupd/6.1.28 66 KirklandJ

Cationic systems like polyplex systems can escape from the endosomes/lysosomes because they have the ability to buffer pH and cause osmotic swelling of these organelles according to the so-called "proton sponge-mediated escape" theory

Dihydroartemisinin (DHA) induces oxidative stress in cancer cells by increasing intracellular reactive oxygen species (ROS)