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Jumper's knee

Evidence suggests that prescription retinoid-containing products are the most likely candidate to lead to severe congenital irregularities

However, when this signal is too strong or prolonged, it damages liver cells, leading to disease progression

For within-subject comparisons over time, the multivariate approach to repeated measures or the Mann-Whitney U test was applied because Mauchlys test indicated a violation of the sphericity assumption

Running them together is expected to make these effects more frequent and more intense during the co-escalation phase (roughly weeks 9-20 in the staggered protocol)