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Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts

Access this article Similar content being viewed by others Abbreviations AIF: All ion fragmentation CID: Collision-induced dissociation m -CPP: 1-(3-Chlorophenyl)piperazine DDA: Data-dependent acquisition DMSO: Dimethyl sulfoxide ESM: Electronic supplemental material GSH: Glutathione GSH-EE: Glutathione ethyl ester HCD: Higher energy collisional dissociation HRMS: High-resolution mass spectrometer LC: Liquid chromatography LC-MS: Liquid chromatography-mass spectrometry MDF: Mass defect filter MRM: Multiple reaction monitoring MS: Mass spectrometry MS/MS: Tandem mass spectrometry NADPH: -Nicotinamide adenine dinucleotide 2-phosphate reduced tetrasodium salt NMR: Nuclear magnetic resonance RT: Retention time SIM: Selected ion monitoring S/N: Signal-to-noise XIC: Extracted ion chromatograms References Leung L, Kalgutkar AS, Obach RS

2024 Jul 13];9(5):2796-808

Xiao et al., 2025b)

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