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The correlation matrices for these analyses and the comparison of significant correlations between young and older adults can be found in Supplementary Tables S7S11

This is well illustrated by the velocity equation for the CBS reaction, the first step in the transsulfuration pathway: The first factor is simply Michaelis-Menten kinetics for the CBS reaction that uses homocysteine (Hcy) and serine (Ser) as substrates

( H and I ) Cells were exposed to control or HR injury and collected for ChIP assay

These sites accumulate at stalled replication forks or at sites of single-strand damage

Our findings suggest that nonvesicular lipid transfer from the ER contributes to myelin biogenesis (Fig