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While the potential of dietary interventions to influence systemic diseases of the whole body is supported by various studies, a critical outlook reveals the necessity for more rigorous, long-term clinical trials to validate these findings

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Human efficacy and long-term safety data are not yet available, so applications remain strictly within laboratory research

* Correspondence: Xiaoting Zhai, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

7.2 Signaling pathway driven-activation (polarization) of central glial cells Mitogen-activated protein kinases (MAPK) signaling pathway: Activation of central glial cells is primarily characterized by morphological changes, upregulation of classical activation markers, expansion of cell populations, and enhanced pro-inflammatory responses