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Leriglitazone not only improves redox balance and mitochondrial biogenesis, more importantly, but it also inhibits the activation of NF-B to control inflammation and effectively decreases pro-inflammatory biomarkers in plasma and cerebrospinal fluid in healthy volunteers, which is very important for the treatment of severe cerebral form ( Preclinical Studies of X-Linked Adrenoleukodystrophy for New Therapy Studies on SIRT1 show evidence for its role in preventing oxidative stress and inflammation (117)

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