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Metformin and thiazolidinedione have additional advantage of improving insulin resistance and decreasing visceral fat accumulation

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For ion homeostasis there is a need for a constant membrane potential and cell volume as well as to regulate intracellular Na + and K + ions essential for the activity of several enzymes in the cytosol (Farooq et al., 2015)

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Secondly, glutathione content in the atrial tissue is diminished by 58% in NYHA class IV patients compared to NYHA class I patients, and the degree of its decrease in CAD patients correlates with LVEF decline