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(1) Neurodevelopmental Homeostasis: In the healthy state, mitochondrial oxidative phosphorylation (Complexes IV) supports efficient ATP generation, redox stability, and formate flux from the mitochondrial folate cycle (via SHMT2, MTHFD2)

Tight junctions, a collection of cytosolic and transmembrane proteins connected to the cytoskeleton, are key determinants of paracellular permeability[17]

DOI: 10.1016/j.tifs.2015.06.003 24

[DOI] [PMC free article] [PubMed] [Google Scholar] 153.Ijssennagger N., van der Meer R., van Mil S.W.C

These ingredients work together to protect cells from oxidative stress, a known trigger for melasma, and inhibit unnecessary inflammatory activities that could exacerbate melasma