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Small molecules directly targeting the clock proteins offer the potential to directly manipulate endogenous circadian rhythm to improve clock-regulated output processes, as well as to treat diseases associated with clock misalignment (for a comprehensive review on the topic see 135

Nanocarriers, however, have shown promising results in crossing the BBB and delivering ADCs directly to brain tumors [403,404,405]

WolburgHWolburg-BuchholzKKrausJRascher-EggsteinGLiebnerSHammSet al

TP53 MITE library screen with APR-246 Appropriate cell lines were infected with the TP53 MITE library viral supernatant supplemented with polybrene infection reagent (5g/mL) and selected with puromycin (15g /mL) for 1014 days