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Expression of LKB1 tumor suppressor in non-small cell lung cancer determines sensitivity to 2-deoxyglucose

10.1177/0960327118816137 Hum

Mammalian cells have two distinct RNR enzymess that both share a common catalytic R1 subunit, but differ in their second subunit, with one isoform being S phase-specific and containing R2 protein and the other being expressed throughout the cell cycle as well as in post-replicative cells and having a distinct protein, p53R2, as the second subunit (Avval and Holmgren, 2009

The researchers suggested that zinc concentrations could have clinical use, as low zinc concentrations were associated with malignant tumors, and increasing concentrations after treatment were associated with worse prognostic

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