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Lipoylation, a critical post-translational modification for TCA cycle enzymes, including pyruvate dehydrogenase, -ketoglutarate dehydrogenase, branched-chain -ketoacid dehydrogenase and the glycine decarboxylase complex, enhances their catalytic activity under normal conditions (159)

In addition, EGCG could induce a decrease in the global DNA methylation level in the human epidermoid carcinoma A431 cell by reducing the mRNA and protein levels of DNMT1, DNMT3a, and DNMT3b, especially for TSGs, p16INK4a, and Cip1/p21 (Nandakumar et al., 2011)

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Weeks 12-16 mark the typical timeframe for visible thickness and density changes