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In an in vitro H9c2 cell model subjected to hypoxia/reoxygenation, AS-IV upregulated the expression of GATA-binding protein 4 (GATA-4), Bcl-2, and P62, while downregulating apoptosis and autophagy-associated genes such as PARP, caspase-3, and Beclin-1

"A pilot study to assess the effect of a three-month vitamin supplementation containing L-methylfolate on systemic homocysteine plasma concentrations and retinal blood flow in patients with diabetes", Molecular Vision

Endothelial impairment is an early risk marker for atherogenesis and vascular disease progression