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Metabolic, cognitive and mental support Thiamine (Vitamin B1) contributes to normal energy metabolism and the proper functioning of the nervous system

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DeFeudis Professor of Biomedical Research University of Massachusetts Medical School Copyright 2015-2026 Linus Pauling Institute Figure Alternative Text Figure

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By inhibiting autophagy and inducing mitochondrial ROS, TMAO activates NLRP3 inflammasome, leading to the release and pyroptosis of IL-1/IL-18 dependent on caspase-1 in colon epithelium, which is a hallmark of IBD severity

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