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Furthermore, to prevent irritation and maintain microbial defense, the pH of the nasal formulation should be adjusted slightly acidic, as lysozymes in nasal secretions effectively destroy bacteria at acidic pH but become inactivated under alkaline conditions, leaving tissue vulnerable to infection [101]

doi: 10.1159/000082182 11 PandolSJSalujaAKImrieCWBanksPA

[2] It has also been utilized historically in diagnostic provocation tests (e.g., to stimulate growth-hormone release) and as an irrigating fluid in surgical settings (in much more diluted form)

To date, 17 double-blind, randomized, placebo-controlled trials of mitochondrial modulators such as N -acetylcysteine and inositol in treating OCD have been conducted (Table 1)

Animals were fed ad libitum a diet prepared according to the American Institute of Nutrition (AIN-93M) for adult rats (Reeves et al., 1993)