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As cell mass continues to decrease, the increased metabolic demand, continuous exposure to pro-inflammatory cytokines, and sustained hyperglycemic conditions upregulate mitochondrial and ER stress in cells, which further impair cell function and promote stress-mediated stress (179188)

doi: 10.1016/j.neurobiolaging.2015.09.015

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Glutathione is typically well-tolerated since it is a substance the body already knows

Considering the unique ADME characteristics of toxic substances, recent studies have integrated toxicity prediction with ADME modeling, collectively referred to as ADMET prediction