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References Mimura, Y

Data from animal and human studies show that apigenin is quite safe at high doses and no toxicity has been reported [256, 257]

An investigation of apoptotic responses following adenovirus-mediated p53 gene delivery

Notably, XO activity is associated with obesity-related metabolic dysfunction, and XO inhibitors typically prescribed for gout or hyperuricemia are proving to be effective in mitigating cardiovascular and renal complications of diabetes (504, 507, 508)