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Superoxide dismutase (SOD), a critical antioxidant enzyme that neutralizes harmful superoxide radicals, also requires copper, and GHK-Cu supports antioxidant defenses through this pathway

Ma et al., Intracellular delivery of itaconate by metal-organic framework-anchored hydrogel microspheres for osteoarthritis therapy

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However, ferroptotic tumor cells may also reduce the secretion of TGF1, which is detrimental to the recruitment of immunosuppressive cancer-associated fibroblasts (CAFs) into the TME [153]

42 GenuaM.PandiniG.SisciD.CastoriaG.MaggioliniM.VigneriR.et al (2009)