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While both doses were safe, participants on methylcobalamin did not experience a significantly slower functional decline, as assessed with the ALS Functional Rating Scale Revised (ALSFRS-R), than those on a placebo, failing to meet the studys main goal

10.1523/jneurosci.5200-05.2006 276 RomeraC.HurtadoO.MallolasJ.PereiraM

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In T-ALL models, anti-ICAM-1 antibodies significantly decreased mitochondrial transfer from MSCs to cancer cells [411]

This protective effect is mediated through upregulation of GPX4 and FTH1, and downregulation of COX-2, highlighting OLR1 as a key regulator of ferroptosis in ICH (187)