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Therapy with D-penicillamine is effective in many cases and liver transplantation can be curative

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The changes are meant to: Clarify regulated software product boundaries (which includes exemptions and exceptions), Introduce new classification rules, Update the essential principles so that requirements for SaMDs are more clearly expressed

These plaques are primarily composed of lipids, fibrous tissue, and calcium, and they are prone to secondary complications such as calcification, ulceration, thrombus formation, and intraplaque hemorrhage 1,2

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