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These observations highlight a major limitation of first-generation KRAS inhibitors: while direct KRAS inhibition is feasible, durable disease control remains difficult to achieve with monotherapy

Furthermore, we cannot disentangle the potential effect of confounding factors, such as fluctuations of other sex hormones during the menstrual cycle

This improvement was not significantly different in the surgical vs

However, because no other meaningful changes had been made to my TRT protocol, it reinforced the importance of repeating blood work whenever introducing a new variable