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The pathological process mainly involves disruption of immune tolerance in lymphoid organs, dysregulation of intracellular signaling and impaired differentiation of regulatory T-cells, which not only affects the normal functioning of the immune system, but also promotes inflammatory responses and tissue damage through a variety of mechanisms (23)

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[DOI] [PubMed] [Google Scholar] 146.Schwartz L., Buhler L., Icard P., Lincet H., Steyaert J.M