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There are over 25,000 scientific studies and research articles published on Curcumin that validate its amazing antioxidant and anti-inflammatory properties

On the one hand, they can repair the integrity of the damaged intestinal barrier and promote the enrichment and metabolic activity of protective flora (such as Akkermansia and Lactobacillus ), thereby down-regulating the low-grade chronic inflammation in the whole body and local joints through the gut-joint axis. On the other hand, they can directly inhibit the iron-dependent lipid peroxidation cascade reaction in chondrocytes (such as regulating the GPX4, NRF2 pathways and the expression levels of proteins implicated in iron metabolism) to block or delay the ferroptosis of chondrocytes

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Differential effect of nitric oxide on glutathione metabolism and mitochondrial function in astrocytes and neurones: implications for neuroprotection/neurodegeneration

Oral and combination regimens have also shown improvement in melanin indices and overall tone ( Weschawalit et al., Journal of Biomedical Biotechnology, 2017