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Yang and co-workers reported a nanomedicine composed of dendritic mesoporous silica nanoparticles (DMSNs), Fe 3 O 4 , Mn, and glutaminase inhibitor Telaglenastat (CB-839) (termed DFMC) for restored oxaliplatin chemosensitivity on the basis of the GSH-responsive and -exhausting effect (Figure 4C) (Wu et al., 2022

These -Glu-AAs can be transported back into cells, where they become substrates for the enzyme -glutamyl cyclotransferase

Additionally, oxidative stress in excess is understood to participate in the dysregulation of cellular processes and disease development (Zewen et al

Jones DP

Mannick JB, Schonhoff C, Papeta N, Ghafourifar P, Szibor M, Fang K et al