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We considered the possibility that diminished ER stress, improved ER ultrastructure, and delayed protein maturation and secretion might together be explained by more stringent ER quality control

Using random forest regression as the predictive model, we identified pathways commonly associated with NRF2, such as reactive oxygen species (ROS) and xenobiotic metabolism, in addition to reduced glutathione and NADP levels, as top features associated with NRF2 dependency (Fig