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ROS further modulate the nuclear factor kappa B (NF-B) pathway (Lingappan, 2018) and induce oxidative modifications of transcription factors (e.g., Nrf2, p53), altering their stability and activity in cancer-related processes (Humpton et al., 2022)

Furthermore, we found that LTR had significant increases in serine and inosine, which are required for optimal T cell proliferation, enhanced adoptive immunotherapy, and can reverse CAR T cell exhaustion in preclinical models 15,16 , as well as lactic acid, which preclinically improves adoptive immunotherapy 17 and might be related to increased LDHA expression seen in this group (Fig

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DNA methylation analysis of the SHOX2 and RASSF1A panel in bronchoalveolar lavage fluid for lung cancer diagnosis