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However, pretreatment with L-carnitine (0.1 ~ 1 mM) prevented a further increase in MDA levels

Embodiment 67 of this disclosure are compounds of Formula I, I-a, or I-b, or Embodiments 1-66, or a class thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein R 9 is O, CH 3 , CH 2 CH 3 , F, CF 3 , CH 3 CN, C(O)cyclopropyl, C(O)EtO, CH(CH 3 ) 2 , or C(O)NHCH(CH 3 ) 2 , or a 6 membered heterocycle containing one Oxygen and one Nitrogen atom

During the process of literature screening, we followed the principles of rigor and order

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This ensures sustained homocysteine flux, which is critically converted to cysteine for GSH biosynthesis when the canonical cystine/glutamate antiporter (system xc-) is inhibited, a common trigger for ferroptosis (Cao et al., 2020)