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Regarding small molecule inhibitors targeting NNMT, challenges include the identification of efficient and selective inhibitors with robust in vivo activity (Barrows et al., 2022)

These early changes reflect the peptides activation of lipolytic pathways and increased fat oxidation, though visible physical changes are not yet apparent

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In animal studies, BPC-157 has shown protective effects in central nervous system injury models and nasal peptide delivery can allow compounds to reach brain tissues, so scientists are exploring whether it may help reduce nerve inflammation and support recovery after injury