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The negative effects of DHA accumulation on the growth of neurites in neurospheres have been linked to the redox imbalance that favors an increase in reactive oxygen species (ROS) production, inducing an irreversible process of protein oxidation, including the carbonylation of cytoskeletal proteins such as actin and tubulin, thus inhibiting the maintenance of neurites ( Previous studies have shown that DHA accumulation in neuronal cells induces rapid glutathione consumption, inhibits glycolysis, and activates the pentose phosphate pathway (PPP) (Yun et al., 2015)

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doi:10.1024/0301-1526/a000600 Nyvad J, Lerman A, Lerman LO