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Fabozzi G, Rebuzzini P, Cimadomo D et al (2022) Endocrine-disrupting chemicals, gut microbiota, and human (in)fertilityit is time to consider the triad

Similar content being viewed by others Introduction - from energy deficiency to chronic inflammation Inflammatory bowel diseases (IBD) are a paradigm for the complex interplay of gene-environment interactions in the development and progression of immune-mediated pathologies, and together with metabolic disorders, their incidence and prevalence are increasing, following a pattern of industrialization 1,2

Nevertheless, due to the longterm use of adrenaline as a chronic antiglaucoma therapy after World War II, we now know that it can sometimes cause hyperpigmentation of the conjunctiva and, very rarely, of the cornea, but not of the iris (Domarus, 1977)

However, a majority of the patients reach adulthood without any other symptoms than decreased stamina and fatigue 20,21

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