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Drugs 29 , 443459 (2020)

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Mitochondrial reactive oxygen species drive proinflammatory cytokine production

Next, electrons supplied by the cofactor nicotinamide adenine dinucleotide phosphate (NADPH) are transferred to the CYP by two intramembrane proteins, cytochrome P450 reductase and cytochrome b5, reducing the heme iron to the ferrous (Fe 2+ ) state

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