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To demonstrate that melatonin supplementation alleviates ovarian oxidative damage by enhancing the H3K18la-STEAP3 axis through metabolic reprogramming and lactate accumulation, we first examined the expression of key glycolysis-related genes, including HK2 , 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase ( PFKFB ), Lactate Dehydrogenase A (LDHA), and blood lactate levels

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