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Principal component analysis and metabolic pathway analysis of metabolomics data MetaboAnalyst was used for pathway analysis and performs metabolite set enrichment analysis, which includes a set of human and mammalian metabolites and a set of chemical grade metabolites

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It is also possible that hypothalamic/pituitary autoimmunity may be present in ME/CFS- particularly in the more severe cases- as antipituitary and antihypothalamic antibodies have been identified (430)

Although the causes could be complex, lysosomal dysfunction by Dimebon could have potentially contributed to the failure to demonstrate therapeutic benefit, and further evaluation of the autophagy enhancing effects of the drug would be valuable