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The fragrance isnt just refreshing

Harmonic restraints of 50.0 kcal mol 1 2 were applied to the solutes, including the crystallographic ions, to allow solvent relaxation while preserving the maximum fidelity to the docking pose, and the Andersen temperature coupling scheme 81,82 was used to control and equalize the temperature

This change may be due to an expansion given the simultaneous loss of intramolecular hydrogen bonds (see Fig

These positive effects of AST significantly decreased in the AST + FLU (0.5 mg/kg) and AST + NAL (0.1 mg/kg) groups (Figure 10)

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