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However, clinical trial results are not the only factor that matters in real-world decision-making

Since 2008, the in-hospital mortality rate of patients with acute ST-segment elevation myocardial infarction who received these treatments has decreased from 20% to 5%, marking a significant improvement from the late 1980s [21]

(2012) 142:15361546.e5

There was also mild gastric wall edema and several fluid-filled loops of small bowel with mild thickening, suggestive of possible enteritis

The rationale is straightforward: a 120kg individual has significantly more tissue volume for the peptide to distribute through than a 70kg individual, which affects both the effective concentration at receptor sites and the perceived intensity of side effects